Antibacterial electrospun poly(-caprolactone)/ascorbyl palmitate nanofibrous materials

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• 作者：Dilyana Paneva^a ; Nevena Manolova^a ; ^{manolova@polymer.bas.bg"" rel=""nofollow} ; Mariana Argirova^b ; Iliya Rashkov^a ; ^{rashkov@polymer.bas.bg"" rel=""nofollow}
• 关键词：Ascorbyl palmitate ; Electrospinning ; Silver nanoparticles ; Antioxidant activity ; Antibacterial activity ; Poly( ; //www.sciencedirect.com/scidirimg/entities/25b.gif"" alt=""var epsilon"" title=""var epsilon"" border=""0"">-caprolactone)
• 刊名：International Journal of Pharmaceutics
• 出版年：2011
• 出版时间：15 September 2011
• 年：2011
• 卷：416
• 期：1
• 页码：346-355
• 全文大小：1808 K

文摘

The one-step incorporation of ascorbyl palmitate (AP), a widely used derivative of vitamin C, into nanofibrous mats of poly(-caprolactone) (PCL) by electrospinning was demonstrated. The incorporation of AP was attested by IR spectroscopy; the AP content was determined by thermogravimetric analysis (TGA); and the surface composition of the mats: by X-ray photoelectron spectroscopy (XPS). The possibility for deposition of silver nanoparticles onto PCL/AP mats using the ability of AP to reduce silver ions was demonstrated. The silver content was determined by TGA, and the silver nanoparticles were observed by transmission electron microscopy (TEM). The nanoparticles were composed of elemental silver, as verified by XPS analyses. The UV–vis spectrophotometric analyses, study on quenching of the free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and microbiological tests against the pathogenic microorganism Staphylococcus aureus showed that AP preserved its stability and its antioxidant and antibacterial activity when incorporated in the nanofibrous mats.