Sporadic Creutzfeldt-Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3γ assay
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- 作者：M.J. Leitã ; oa ; d ; e ; jajao86@gmail.com" class="auth_mail" title="E-mail the corresponding author ; I. Baldeirasa ; d ; e ; M.R. Almeidae ; M.H. Ribeiroa ; d ; A.C. Santose ; M. Ribeiroe ; J. Tomá ; sb ; S. Rochac ; I. Santanab ; d ; e ; C.R. Oliveiraa ; b ; d ; e
- 关键词：α-syn ; alpha-synuclein ; AD ; Alzheimer&rsquo ; s disease ; ApoE ; apolipoprotein E gene ; CNS ; central nervous system ; CSF ; cerebrospinal fluid ; CV ; coefficient of variation ; EEG ; electroencephalogram ; ELISA ; enzyme-linked immunosorbent assay ; ERK ; extracellular signal-regulated protein kinase ; LP ; lumbar puncture ; MRI ; magnetic resonance imaging ; PRNP ; prionic protein gene ; PrPSc ; scrapie prion protein ; p-Tau ; phosphorylated Tau protein ; RT-QuIC ; real time quaking induced conversion ; sCJD ; sporadic C
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：398-407
- 全文大小：471 K
文摘
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We quantified CSF 14-3-3γ in 72 sCJD and 73 Non-CJD patients, by a new ELISA assay.
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WB and ELISA 14-3-3γ results matched in 81% of all cases.
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WB inconclusive cases were further discriminated by ELISA 14-3-3γ assay.
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ELISA 14-3-3γ is the best single predictive marker for sCJD early diagnosis.
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PRNP genotype did not influence ELISA 14-3-3γ protein levels.