Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus
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- 作者：Patrick L. Harrisona ; Mohamed A. Abdel-Rahmanb ; Peter N. Stronga ; Mohamed M. Tawfika ; Keith Millera ; K.miller@shu.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pore forming peptides ; Infection ; Scorpion venom ; Venomics ; Therapeutics
- 刊名：Toxicon
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：30-36
- 全文大小：746 K
文摘
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Three antimicrobial peptides were derived from the venom of Scorpio maurus palmatus.
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Two of these peptides, Smp24 and Smp43, have promising membrane disruptive activities.
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A hinge-helical-hinge conformation promotes prokaryotic specificity in scorpion-derived antimicrobial peptides.