From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma
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- 作者：Charlotte Lepoutre-Lusseya ; b ; Constance Thibaulta ; b ; Alexandre Buffeta ; b ; Auré ; lie Morina ; b ; Cé ; cile Badouala ; b ; c ; Paule Bé ; nitd ; e ; Pierre Rustind ; e ; Chris Ottolenghib ; f ; g ; Maxime Janinb ; f ; g ; Luis-Jaime Castro-Vegaa ; b ; Jan Trapmanh ; Anne-Paule Gimenez-Roqueploa ; b ; i ; Judith Faviera ; b ; judith.favier@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pheochromocytoma ; Genetically engineered mouse ; Knockout ; Xenograft ; Chromaffin cells
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：421
- 期：Complete
- 页码：40-48
- 全文大小：1275 K
文摘
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Pheochromocytomas and paragangliomas are genetically determined in 40% of cases.
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PPGL are classified in either the Cluster 1 (pseudohypoxic) or the cluster 2 (MAPK/mTOR).
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Several Cluster 2-related knockout mouse models are predisposed to pheochromocytoma.
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No Cluster 1-related knockout mouse models ever developed a pheochromocytoma.
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Xeno- and allograft models are an alternative to test new therapeutic strategies.