Sequestering ability to Cu^{2 +} of a new bodipy-based dye and its behavior as in vitro fluorescent sensor

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• 作者：Teresa Papalia^a ; ¹ ; ^{teresa.papalia@unirc.it} ; Anna Barattucci^a ; ^{abarattucci@unime.it} ; Davide Barreca^a ; ^{dbarreca@unime.it} ; Ersilia Bellocco^a ; ^{ebellocco@unime.it} ; Paola Bonaccorsi^a ; ^{pbonaccorsi@unime.it} ; Lucio Minuti^b ; ^{lucio.minuti@unipg.it} ; Marco Sebastiano Nicolò ; ^a ; ^{mnicolo@unime.it} ; Andrea Temperini^c ; ^{andrea.temperini@unipg.it} ; Claudia Foti^a ; ^{cfoti@unime.it}
• 关键词：Cu2  ; + sensor ; Bodipy ; Fluorescence ; Complexing ability ; Cell internalization
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：116-123
• 全文大小：886 K
• 卷排序：167

文摘

A Bodipy (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-based chemosensor was synthesized. Sensor shows selective sequestering properties towards Cu2 + at micromolar concentrations. The sensor crosses membrane of erythrocytes and colors them with a red fluorescence. The sensor is sensible to Cu2 + variation in the erythrocytes.