The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor
详细信息 查看全文
- 作者：Keita Tagamia ; b ; c ; ktagami@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Yohei Kashiwasea ; d ; yohei090109@outlook.jp" class="auth_mail" title="E-mail the corresponding author ; Akinobu Yokoyamaa ; d ; ayoko65@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hitomi Nishimuraa ; d ; 3B14679@ed.tus.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kanako Miyanoa ; kmiyano@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Masami Suzukia ; masamsuz@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Seiji Shiraishia ; sshirais@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Motohiro Matobae ; teamkanwa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuichiro Ohec ; f ; yohe@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Yasuhito Uezonoa ; g ; h ; yuezono@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anorexia ; Appetite ; Ca2 ; + imaging assay ; CellKey&trade ; system ; Ghrelin ; Growth hormone secretagogue receptor ; Haloperidol ; Olanzapine
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：93-101
- 全文大小：846 K
文摘
- •
The orexigenic mechanism of olanzapine has not been clarified.
- •
We examined the association between this effect and ghrelin receptor signaling.
- •
We examined this relationship by using cellular impedance and Ca2 + imaging assays.
- •
Olanzapine enhanced the ghrelin receptor-mediated signaling induced by ghrelin.
- •
Olanzapine may promote appetite by enhancing ghrelin receptor signaling.