Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics
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- 作者：A.D. Martinsa ; b ; R. Sá ; a ; b ; M.P. Monteirob ; c ; A. Barrosd ; e ; f ; M. Sousaa ; b ; d ; R.A. Carvalhog ; B.M. Silvah ; P.F. Oliveiraa ; b ; f ; M.G. Alvesg ; h ; alvesmarc@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ghrelin ; Sertoli cells ; Growth hormone secretagogue receptor ; Spermatogenesis ; Obesity
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：199-209
- 全文大小：1382 K
文摘
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Human Sertoli cells (hSCs) express the growth hormone secretagogue receptor.
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Exposure to ghrelin levels is inversely associated with lactate production by hSCs.
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Ghrelin levels of severely undernourished individuals had more pronounced effects.
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Ghrelin regulates energy status of hSCs cells in a dose-dependent manner.