Phosphatidylcholine as a metabolic cue for determining B cell fate and function

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• 作者：Joseph W. Brewer^b ; Viktoriya Solodushko^a ; Ileana Aragon^a ; Robert A. Barrington^a ; ^{rbarrington@southalabama.edu}
• 关键词：CCTα ; Antibody-secreting cell ; Antibody ; Germinal centers ; T cell-dependent antigen ; Unfolded protein response ; Phospholipid biosynthesis
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：78-88
• 全文大小：1626 K
• 卷排序：310

文摘

CCTα is required for antigen-specific, germinal center-derived antibody-secreting cells. CCTα is required for antigen-specific, germinal center-derived memory B cells. Phosphatidylcholine is required for germinal center B cell responses.