A working model for the type III secretion mechanism in Chlamydia

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• 作者：Joshua C. Ferrell ; Kenneth A. Fields ; ^{Ken.fields@uky.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pathogenesis ; Effector ; Secretion
• 刊名：Microbes and Infection
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：18
• 期：2
• 页码：84-92
• 全文大小：531 K

文摘

It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.