Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine
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- 作者：Theodore A. Slotkin ; t.slotkin@duke.edu" class="auth_mail" title="E-mail the corresponding author ; Ashley Stadler ; Samantha Skavicus ; Frederic J. Seidler
- 关键词：ANOVA ; analysis of variance
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：71-75
- 全文大小：494 K
文摘
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Nicotine increases heart norepinephrine in adult rats, and spikes upon withdrawal.
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This response is absent in adolescents given nicotine.
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Adolescents instead show later-emerging, persistent changes in heart norepinephrine.
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Adolescent nicotine may produce less aversive autonomic responses to withdrawal.
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Persistent effects are consistent with elevated risk of hypertension and CHD.