Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine
详细信息 查看全文
- 作者：Carl L. Faingold ; cfaingold@siumed.edu" class="auth_mail" title="E-mail the corresponding author ; Marc Randall ; Srinivasa P. Kommajosyula
- 关键词：SUDEP ; Adenosine ; DBA/2 mice ; Caffeine ; Respiratory arrest
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：49-54
- 全文大小：768 K
文摘
- •
The DBA/2 mouse model of SUDEP is modulated by adenosine.
- •
Most DBA/2 mice exhibit seizure-induced respiratory depression (S-IRA).
- •
An agent that inhibits adenosine breakdown increases S-IRA susceptibility.
- •
Agents that block adenosine receptors decrease S-IRA susceptibility.
- •
SUDEP prevention may be improved by administering adenosine antagonists.