Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model

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• 作者：K. Nakase^a ; R. Kollmar^b ; ^c ; J. Lazar^d ; H. Arjomandi^c ; K. Sundaram^c ; J. Silverman^c ; R. Orman^a ; J. Weedon^e ; D. Stefanov^e ; E. Savoca^b ; ^c ; L. Tordjman^a ; K. Stiles^b ; M. Ihsan^d ; A. Nunez^d ; L. Guzman^g ; M. Stewart^a ; ^f ; ^{mark.stewart@downstate.edu}
• 关键词：SUDEP ; Larynx ; Asphyxiation ; Arrhythmia ; Cardiopulmonary arrest
• 刊名：Epilepsy Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：128
• 期：Complete
• 页码：126-139
• 全文大小：4560 K
• 卷排序：128

文摘

Seizure activity spreads to laryngeal motor neurons to cause laryngospasm. Laryngospasm results in partial or complete airway occlusion. Seizure activity changes breathing frequency, amplitude, variability, and can cause central apnea. Only obstructive apnea was associated with rapid, severe arterial oxygen desaturation, bradycardia, and death. Sudden death is the result of respiratory arrest during airway obstruction and nearly simultaneous LV dilatation and asystole.