Evolution of hepatitis C virus in HIV coinfected patients under antiretroviral therapy
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- 作者：Mariano Sedea ; b ; Micaela Parraa ; b ; Julieta M. Manriquea ; c ; Natalia Laufera ; b ; Leandro R. Jonesa ; c ; 1 ; lrj000@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jorge Quarleria ; b ; 1 ; quarleri@fmed.uba.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCV ; HIV ; E1/E2 gene ; Haplotypes ; Phylogeny ; Temporal structuring
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：186-196
- 全文大小：1562 K
文摘
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HAART-induced CD4 + T-cell recovery shapes intra-host HCV evolution.
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10">A host-dependent HCV temporal structuring phenomenon is proposed.
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15">The positive selection pressure on the E2-HVR1 domain shows dissimilar magnitudes.
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At HCV E2 gene, the occurrence of intra-subtype recombination is uncommon.