Mutant IDH1 decreases hematopoietic stem cell (HSC) number and impairs self-renewal
Mutant IDH1 causes TET2-independent downregulation of ATM via methylation of H3K9
Mutant IDH1 causes accumulation of DNA damage and impairs DNA repair in HSCs
Mutant IDH1 increases HSC sensitivity to radiation and daunorubicin