Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase
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- 作者：Sara Larsson sara.larsson@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Helena A. Jones helena.jones@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Olga Gö ; ransson olga.goransson@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Eva Degerman eva.degerman@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Cecilia Holm ; cecilia.holm@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; AMP-activated protein kinase ; ATGL ; adipose triglyceride lipase ; CaMK ; Ca2 ; +/calmodulin-dependent protein kinase ; ERK ; extracellular-regulated kinase ; HSL ; hormone-sensitive lipase ; PDE ; phosphodiesterase ; PKA ; protein kinase A ; PKB ; protein kinase B ; PTH ; parathyroid hormone ; PTHrP ; PTH-related protein ; PTH1R ; PTH type 1 receptor ; PTH2R ; PTH type 2 receptor
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：28
- 期：3
- 页码：204-213
- 全文大小：1383 K
文摘
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PTH (1-84), PTH (1-37) and PTHrP stimulates adipocyte lipolysis.
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The lipolytic action of PTH is paralleled by phosphorylation of HSL and perilipin 1.
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Inhibition of PKA blocks the lipolytic action of PTH.
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Inhibition of ERK, PKB, AMPK or CaMK has no effect on the lipolytic action of PTH.
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Inhibition of PDE4 strongly potentiates the lipolytic effect of PTH.