Hormone-sensitive lipase deficiency disturbs lipid composition of plasma membrane microdomains from mouse testis
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- 作者：Marí ; a E. Casadoa ; b ; 1 ; Oscar Pastorc ; 1 ; David Garcí ; a-Seisdedosc ; Lydia Huertaa ; Fredric B. Kraemerd ; Miguel A. Lasunció ; na ; b ; Antonia Martí ; n-Hidalgoa ; b ; antonia.martin@hrc.es" class="auth_mail" title="E-mail the corresponding author ; Rebeca Bustoa ; b ; rebeca.busto@hrc.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Abcg1 ; ATP-binding cassette transporter G1 ; BCA ; bicinchoninic acid ; C ; carbon atoms ; Cyp51 ; lanosterol 14α-demethylase or 14α-sterol demethylase ; CypB ; cyclophilin B ; db ; double bonds ; Dhcr24 ; desmosterol reductase or sterol ∆24-reductase ; Elovl 2 ; elongase of very-long chain fatty acid 2 ; Fads ; fatty acid desaturase ; FF-MAS ; follicular fluid meiosis activating sterol ; Hmgcr ; 3-hydroxy-3-methyl-glutaryl-CoA reductase ; HSL ; hormone-sensitive lipase ; KO ; knock-out ; PC ; phosphatidylcholine ; P
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：1142-1150
- 全文大小：1226 K
文摘
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HSL ablation alters the density of lipid-raft microdomains in mouse testis.
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HSL−/− lipid rafts had less desmosterol and T-MAS; non-raft had more cholesterol.
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Monounsaturated acyl phospholipids were higher in raft than in non-raft fractions.
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HSL ablation reduced PUFA-phospholipids in both raft and non-raft fractions.