- 作者：M. Ussat ; C. Vogtmann ; C. Gebauer ; F. Pulzer ; U. Thome ; M. Knü ; pfer ; knuem@medizin.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：adOR ; adjusted odds ratio ; CI ; confidence interval ; Clin-LOS ; clinical late-onset sepsis ; CNS ; coagulase-negative staphylococci ; cpTD ; central-peripheral temperature difference ; CrP ; C-reactive protein ; CRT ; capillary refill time ; cT ; central temperature ; IL-6 & IL-8 ; interleukin 6 and 8 ; I/T ratio ; immature neutrophil to total neutrophil ratio ; LOS ; late-onset sepsis ; NICU ; neonatal intensive care unit ; No-LOS ; late-onset sepsis was established to be absent ; OR ; odds ratio ; P ; p-value ; PDA ; pat
- 刊名：Early Human Development
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：91
- 期：12
- 页码：677-681
- 全文大小：229 K
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Early detection of late onset sepsis (LOS) in ELBW-infants is still a formidable task. We investigated the association between clinical symptoms and late-onset sepsis (LOS) in 83 episodes of suspected LOS in 67 preterm infants. The most marked association between LOS and symptoms of disturbed circulatory regulation, like prolonged capillary refill time and a greater central-peripheral temperature difference (cpTD) > 2 °C, but not blood pressure changes. So we conclude that prolonged capillary refill time and – more impressive – elevated cpTD were the most useful clinical symptoms for detection of LOS in preterm infants. We especially suggest using cpTD as a predictor of LOS. It is a cheap, non-invasive and readily available tool for daily routines.