p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
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- 作者：Angeles Duran1 ; 7 ; Eloy D. Hernandez1 ; 7 ; Miguel Reina-Campos1 ; 2 ; 7 ; Elias A. Castilla1 ; Shankar Subramaniam3 ; Sindhu Raghunandan3 ; Lewis R. Roberts4 ; Tatiana Kisseleva5 ; Michael Karin6 ; Maria T. Diaz-Meco1 ; mdmeco@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author ; Jorge Moscat1 ; 8 ; jmoscat@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：p62 ; sequestosome-1 ; hepatic stellate cells ; fibrosis ; hepatocellular carcinoma ; non-alcoholic steatohepatitis ; liver cancer ; nuclear receptors ; vitamin D receptor ; inflammation
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：595-609
- 全文大小：7300 K
文摘
- 10">
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10">p62 levels are reduced in hepatic stellate cells (HSCs) in human HCC samples
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15">Loss of p62 in HSCs results in increased fibrosis, inflammation, and HCC
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p62 is critical for VDR:RXR heterodimerization and inhibition of HSC activation
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Enhanced HSC activation by p62 loss impairs VDR signaling and promotes HCC