What does the T_peak-T_end interval reflect? An experimental and model study

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• 作者：Natalia V. Arteyeva ; Sergey L. Goshka ; Ksenia A. Sedova ; Olesya G. Bernikova ; Jan E. Azarov
• 关键词：APD gradient ; ARI dispersion of repolarization ; Repolarization ; Simulation ; Total dispersion ; Tpeak-Tend ; Transmural dispersion
• 刊名：Journal of Electrocardiology
• 出版年：2013
• 出版时间：July-August, 2013
• 年：2013
• 卷：46
• 期：4
• 页码：296.e1-296.e8
• 全文大小：842 K

文摘

Background

It is unclear whether the T_peak-T_end interval is an index of the transmural or the total dispersion of repolarization.

Methods

We examined the T_peak-T_end interval using a computer model of the rabbit heart ventricles based on experimentally measured transmural, apicobasal, and interventricular gradients of action potential duration.

Results

Experimentally measured activation-recovery intervals increased from apex to base, from the left ventricle to the right ventricle, and in the apical portion of the left ventricle from epicardium to endocardium and from the right side of septum to the left side. The simulated T_peak corresponded to the earliest end of repolarization, whereas the T_end corresponded to the latest end of repolarization. The different components of the global repolarization dispersion were discerned by simulation.

Conclusions

The T_peak-T_end interval corresponds to the global dispersion of repolarization with distinct contributions of the apicobasal and transmural action potential duration gradients and apicobasal difference in activation times.