Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams
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- 作者：Mary Gemmela ; Ine Rayenb ; Eva van Donkelaarb ; Tiffany Loftusa ; Harry W. Steinbuschb ; Nikolaos Kokrasc ; Christina Dallac ; Jodi L. Pawluskia ; b ; d ; j.pawluski@gmail.com" class="auth_mail" title="E-mail the corresponding author ; jodi.pawluski@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HIAA ; serotonin&rsquo ; s metabolite ; 5-hydroxyindoleacetic acid ; 5-HT ; serotonin ; DA ; dopamine ; DCX ; doublecortin ; DOPAC ; dopamine&rsquo ; s metabolite dihyroxyphenylacetic acid ; IL ; infralimbic cortex ; NGS ; Normal Goat Serum ; PFC ; prefrontal cortex ; SSRI ; selective serotonin reuptake inhibitor
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：327
- 期：Complete
- 页码：32-43
- 全文大小：767 K
文摘
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Gestational stress and fluoxetine affect the maternal brain in a region-specific manner.
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Stress during gestation increases synaptophysin and serotonin in the PFC, but not hippocampus.
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Fluoxetine reverses the effect of gestational stress on the maternal PFC.
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Fluoxetine during lactation decreases methylation and serotonin in the maternal hippocampus.