Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease

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• 作者：Yan Chen ; MD^a ; Wai-Kay Seto ; MD^b ; ^c ; Lai-Ming Ho ; PhD^d ; James Fung ; MD^b ; ^c ; Man-Hong Jim ; MD^e ; Gabriel Yip ; MD^e ; Katherine Fan ; MD^e ; Zhe Zhen ; MD^a ; Ju-Hua Liu ; MD^a ; Man-Fung Yuen ; MD ; PhD^b ; ^c ; Chu-Pak Lau ; MD^a ; Hung-Fat Tse ; MD ; PhD^a ; ^f ; ^{hftse@hku.hk" class="auth_mail" title="E-mail the corresponding author} ; Kai-Hang Yiu ; MD^a ; ^f ; ^{khkyiu@hku.hk" class="auth_mail" title="E-mail the corresponding author}
• 刊名：The American Journal of Cardiology
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：117
• 期：4
• 页码：640-646
• 全文大小：821 K

文摘

The aim of the study was to evaluate the relation between tricuspid regurgitation (TR) severity and liver stiffness (LS) in patients with TR. A total of 131 patients with various degrees of TR secondary to left-sided heart valve disease were enrolled. Severity of TR was quantitatively assessed by proximal isovelocity surface area–derived effective regurgitant orifice (ERO). Patients were divided into 2 groups: 48 with mild–moderate TR (ERO <0.4 cm²) and 83 with severe TR (ERO ≥0.4 cm²). Transient elastography was used to measure the level of LS, an established marker of liver fibrosis, with the threshold of significant LS set at ≥12.5 kPa. Patients with severe TR had a higher LS and prevalence of significant LS than those with mild–moderate TR. Furthermore, LS and significant LS independently correlated with TR-ERO, right atrial pressure and inferior vena cava (IVC) diameter. The presence of a large TR-ERO (≥0.4 cm²) and IVC diameter (>2.15 cm²) provided a high specificity of 78% for significant LS. In conclusion, the present study demonstrates that TR-ERO, right atrial pressure, and IVC diameter are important parameters associated with LS in patients with TR.