Negative Impact of Unidirectional Host-versus-Graft Killer Cell Immunoglobulin-like Receptor Ligand Mismatch on Transplantation Outcomes after Unmanipulated Haploidentical Peripheral Blood Stem Cell Transplantation for Acute Myeloid Leukemia
详细信息 查看全文
- 作者：Seung-Ah Yahng1 ; Young-Woo Jeon2 ; Jae-Ho Yoon2 ; Seung-Hwan Shin3 ; Sung-Eun Lee2 ; Byung-Sik Cho2 ; Ki-Seong Eom2 ; Yoo-Jin Kim2 ; Seok Lee2 ; Chang-Ki Min2 ; Seok-Goo Cho2 ; Dong-Wook Kim2 ; Jong-Wook Lee2 ; Woo-Sung Min2 ; Hee-Je Kim2 ; 4 ; cumckim@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute myeloid leukemia ; Haploidentical hematopoietic stem cell transplantation ; Killer cell immunoglobulin&ndash ; like receptor ; T cell&ndash ; replete
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：316-323
- 全文大小：723 K
文摘
- •
We analyze the outcomes of T cell–replete haploidentical transplantation in adult patients with acute myeloid leukemia.
- •
Host-versus-graft killer cell immunoglobulin–like receptor (KIR) ligand mismatched hematopoietic stem cell transplantation was associated with a higher relapse rate
- •
Bidirectional KIR ligand–matched hematopoietic stem cell transplantation showed relatively favorable outcome.
- •
The KIR ligand effect was significant in patients in first complete remission at hematopoietic stem cell transplantation.