Inhibition of Japanese encephalitis virus (JEV) replication by specific RNA aptamer against JEV methyltransferase

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• 作者：Seung Ryul Han ; Seong-Wook Lee ; ^{SWL0208@dankook.ac.kr}
• 关键词：Japanese encephalitis virus ; Methyltransferase ; RNA aptamer ; Anti-viral agent
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：687-693
• 全文大小：1091 K
• 卷排序：483

文摘

Identification of RNA aptamer specific to JEV MTase with high affinity. Efficient inhibition of methylation activity of JEV MTase by the RNA aptamer. Efficient inhibition of JEV production in cells by the RNA aptamer. Truncation of the RNA aptamer up to 24-mer with high specificity and affinity. Efficient inhibition of JEV production and replication by the truncated aptamer.