PI3K/SGK1/GSK3β signaling pathway is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia/reoxygenation by hydrogen sulfide
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- 作者：Huan Jianga ; 1 ; Jian Xiaoa ; 1 ; Bo Kanga ; 1 ; Xiaoyan Zhub ; Ni Xinb ; nixinphysiology@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhinong Wanga ; Wangzn007@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：H2S ; Autophagy ; Cardiomyocyte ; Hypoxia/reoxygenation ; PI3K ; SGK1 ; GSK3β
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：345
- 期：2
- 页码：134-140
- 全文大小：1270 K
文摘
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Autophagy in cardiomyocytes was upregulated by hypoxia/reoxygenation (H/R).
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H2S inhibited autophagy in cardiomyocytes exposed to H/R significantly.
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PI3K/SGK1/GSK3β signaling pathway is involved in the anti-autophagy effect of H2S.
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The cardioprotection of H2S attributed partly to its anti-autophagy property.