Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats

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• 作者：Aminu Chika ; Shaibu Oricha Bello
• 关键词：Combretum micranthum G. Don ; Alloxan ; Diabetic rats
• 刊名：Journal of Ethnopharmacology
• 出版年：2010
• 出版时间：4 May 2010
• 年：2010
• 卷：129
• 期：1
• 页码：34-37
• 全文大小：180 K

文摘

Aim of the study

To investigate antidiabetic effect of the leaves of Combretum micranthum G. Don, a medicinal plant used for treating diabetes in Northwestern Nigeria.

Materials and methods

Three doses (100 mg/kg, 200 mg/kg and 400 mg/kg) of the aqueous leaf extract of Combretum micranthum were administered to normal glucose loaded, subdiabetic and diabetic rats.

Results

Of the doses tested, 100 mg/kg of the extract was the most effective. It produces a significant hypoglycaemic and antidiabetic activity comparable to the effect of standard drug (0.6 mg/kg glibenclemide).

Conclusion

This study demonstrated the potential antidiabetic property of aqueous leaf extract of Combretum micranthum thus justifying its traditional usage.