Synthesis of 2,3,6,7-tetramethoxyphenanthren-9-amine: An efficient precursor to access new 4-aza-2,3-dihydropyridophenanthrenes as apoptosis inducing agents

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• 作者：Niggula Praveen Kumar^a ; ¹ ; Pankaj Sharma^a ; ¹ ; T. Srinivasa Reddy^c ; Shalini Nekkanti^a ; Nagula Shankaraiah^a ; ^{shankar@niperhyd.ac.in} ; Guntuku Lalita^b ; S. Sujanakumari^b ; Suresh K. Bhargava^c ; V.G.M. Naidu^b ; Ahmed Kamal^a ; ^{ahmedkamal@iict.res.in}
• 关键词：2 ; 3 ; 6 ; 7-Tetramethoxyphenanthren-9-amine ; 4-Aza-2 ; 3-dihydropyridophenanthrenes ; Perkin condensation ; Cytotoxicity ; Multi-component reaction ; Apoptosis
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：305-317
• 全文大小：3283 K
• 卷排序：127

文摘

A novel phenanthrene amine precursor has been synthesized. A new series of 4-aza-2,3-dihydropyridophenanthrenes was developed. Cytotoxicity on selected cancer cell lines and apoptosis inducing studies. Test compound 10l induced G2/M cell cycle arrest and disruption of F-actin assembly. 10l Inhibited cell migration, caused the collapse of DΨm.