- 作者：Amnon Amit ; Dan Beck ; Lior Lowenstein ; Offer Lavie ; Rachel Bar shalom ; Zohar Kedar and Ora Israel
- 刊名：Gynecologic Oncology
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：100
- 期：1
- 页码：65-69
- 全文大小：90 K
Objective.To assess the role of hybrid PET/CT in the evaluation of patients with cervical cancer.Methods.
75 patients divided into 3 groups. Group 1 consisted of 16 patients prior to radical surgery. Group 2 consisted of 31 patients prior to pelvic radiotherapy. Group 3 had 28 patients who underwent the examination secondary to suspected recurrent disease. Whole body PET and CT were performed respectively on the same device 1 h after injection of 10 mCi FDG. PET/CT results were correlated to histological, radiological and clinical follow-up data. Only women with >6 months follow-up were included.
Results.
In 33 patients, pathohistological examinations for extra cervical lesions were obtained. Correlation with PET/CT examination revealed levels of sensitivity (60 % ), specificity (94 % ), positive (90 % ) and negative predictive values (74 % ). The examination indicated 21 patients with extrapelvic and/or metastatic disease. The follow-up data of this group revealed that 20 patients either died or were alive with active disease, and only one patient was in clinical remission. PET/CT yielded an improved diagnosis for both PET and CT in 43 % of the cases by providing better localization and definition of abnormal FDG uptake.
Conclusions.
Hybrid PET/CT was found to be of value for detection of cervical cancer metastases, decision-making and planning of irradiation therapy. Using this modality may reduce unnecessary surgical interventions, help modify radiation fields and change therapeutic approaches. Detection of advanced diseases on PET/CT correlates with poor prognosis. However, this examination is less accurate in detecting microscopic diseases and lesions smaller than 1.5 cm.