Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3
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- 作者：Bing Zhang ; Lei Fang ; Hui-Mei Wu ; Pei-Shan Ding ; Ke Xu ; Rong-Yu Liu ; rongyuliu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TLR2 ; LTA ; MerTK ; Inflammation ; PI3&thinsp ; K/Akt ; SOCS3
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：98-107
- 全文大小：2376 K
文摘
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LTA that activates TLR2 signaling concomitantly induces activation of MerTK signaling in a time-dependent manner.
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LTA-induced MerTK activation is Gas6-dependent.
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LTA induces activation of Akt and SOCS3 in a MerTK-dependent manner.
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Activation of MerTK signaling negatively regulates TLR2-mediated immune response via PI3K/Akt pathway and SOCS3 protein.