Evaluation of the characterization of thrombi in vitro by optical coherence tomography

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• 作者：Guang Yang^a ; ¹ ; Xiaoyuan Zhang^a ; ¹ ; Qingyang Meng^c ; ¹ ; Dan Ma^d ; ¹ ; Huai Yu^a ; ¹ ; Xuefeng Ren^a ; ¹ ; Bo Lv^a ; ¹ ; Shaosong Zhang^b ; ¹ ; Shuang Yang^a ; ¹ ; ^{dryangshuang@126.com" class="auth_mail" title="E-mail the corresponding author} ; Bo Yu^a ; ¹ ; ^{yubodr@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Optical coherence tomography ; Thrombus ; Erythrocyte
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 October 2016
• 年：2016
• 卷：220
• 期：Complete
• 页码：116-121
• 全文大小：739 K

文摘

The purpose of this study was to provide a new assessable method of the optical coherence tomography (OCT) in characterization of thrombi with different concentrations of red blood cell (RBC).

Methods and results

A series of thrombus models were constructed by using human blood in vitro. The thrombi were made by using human blood with different concentration of RBC (from 1% to 35%). Then tip of an FD-OCT catheter was put on the top of the thrombus to scan. After OCT being performed, all the acquired images were processed by a newly developed software to analyze the RBC levels related thrombus characteristics including attenuation, backscattering and light penetration depth. The attenuation was correlated with RBC concentration up to 9%. However, no apparent change was observed in thrombus with RBC concentration range from 10% to 35%. The same trend was seen in backscattering and penetration depth.

Conclusions

FD-OCT is able to detect thrombus with different RBC concentrations up to 9%.