Protective effects of salicylate on PKA inhibitor (H-89)-induced spatial memory deficit via lessening autophagy and apoptosis in rats

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• 作者：Leila Azimi^a ; Maryam Kachooeian^b ; Fariba Khodagholi^c ; Asal Yans^c ; Soomaayeh Heysieattalab^a ; Gelareh Vakilzadeh^a ; Nasim Vosoughi^a ; Mehdi Sanati^b ; Ghorban Taghizadeh^a ; ^d ; Mohammad Sharifzadeh^a ; ^b ; ^{msharifzadeh@sina.tums.ac.ir}
• 关键词：Salicylate ; Hippocampus ; Spatial memory ; PKA ; Apoptosis ; Autophagy
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：158-169
• 全文大小：1096 K
• 卷排序：150

文摘

Salicylate improves learning and memory and reduces neurodegenerative biomarkers. H-89 inhibits learning and memory and increases neurodegenerative biomarkers. Salicylate reversed the inhibitory effects of H-89 on learning and memory. Salicylate reversed the effects of H-89 on neurodegenerative biomarkers.