Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents

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• 作者：Sharma ; Pratibha ; Rane ; Nilesh ; Gurram ; V.K.
• 关键词：Pyrimido[4 ; 5-d]pyrimidine ; Synthesis ; Antibacterial ; Antifungal ; QSAR ; Molar refractivity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 出版时间：August 16, 2004
• 年：2004
• 卷：14
• 期：16
• 页码：4185-4190
• 全文大小：294 K

文摘

A number of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the potent antimicrobial activity. The quantitative structure–activity relationship investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.