HPMC-based gastroretentive dual working matrices coated with Ca+ 2 ion crosslinked alginate-fenugreek gum gel membrane
详细信息 查看全文
- 作者：Hriday Beraa ; b ; hriday.bera1@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chakravarthy Gainib ; Sanoj Kumarb ; Srimanta Sarkarc ; Shashank Boddupallib ; Sohitha Reddy Ippaguntab
- 关键词：Gastroretentive drug delivery system ; Floating ; Swelling ; Alginate ; Fenugreek gum ; Hydroxypropylmethylcellulose ; Quetiapine fumarate
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：170-181
- 全文大小：1503 K
文摘
- •
Biopolymeric gel coated HPMC based tablets containing QF were developed.
- •
HPMC based core matrices were fabricated by wet granulation method.
- •
A 32 factorial design was adopted to optimize the core tablets.
- •
Coated tablets provided better sustained drug release profile.
- •
Coated tablets displayed superior floating and swelling capabilities.