Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese

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• 作者：Ming-Chuan Hu^a ; Sheng-Yu Lee^b ; ^d ; Tzu-Yun Wang^a ; ^e ; ^f ; Shiou-Lan Chen^a ; Yun-Hsuan Chang^b ; ^c ; Shih-Heng Chen^b ; Chun-Hsien Chu^b ; Chen-Lin Wang^b ; I. Hui Lee^b ; ^d ; ^e ; Tzung Lieh Yeh^a ; ^b ; ^e ; Yen Kuang Yang^a ; ^b ; ^d ; ^e ; Ru-Band Lu^a ; ^b ; ^c ; ^d ; ^e ; ^{rblu@mail.ncku.edu.tw}
• 关键词：ALC ; alcoholism ; BP ; bipolar disorder ; ANX/DEP ALC ; anxiety&ndash ; depression alcoholism ; AS-ALC ; antisocial alcoholism ; MX-ALC ; mixed-type alcoholism ; SADS-L ; Schedule of Affective Disorder and Schizophrenia-Lifetime ; DOPAL ; 3 ; 4-dihydroxyphenyl-acetaldehy
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2013
• 出版时间：10 January, 2013
• 年：2013
• 卷：40
• 期：Complete
• 页码：144-148
• 全文大小：216 K

文摘

Background

Several studies have hypothesized that genes involved in the dopamine system, including dopamine type-2 receptor (DRD2)-related TaqIA polymorphism and monoamine oxidase-A upstream variable number tandem repeat (uVNTR), may be associated with alcoholism. But their results were contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms are susceptibility factors for alcoholism comorbid with bipolar disorder (ALC + BP) in Han Chinese in Taiwan.

Methods

We recruited 101 Han Chinese men with comorbid alcoholism and bipolar disorder, and 328 healthy male controls from the community. Genotyping was done using PCR-RFLP.

Results

There were no significant differences in the genotypic frequencies of the DRD2TaqIA or the MAOA-uVNTR polymorphisms between the 2 groups. The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC + BP (odds ratio = 0.432, p = 0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC + BP (odds ratio = 3.451, p = 0.018).

Conclusions

We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC + BP.