We recruited 101 Han Chinese men with comorbid alcoholism and bipolar disorder, and 328 healthy male controls from the community. Genotyping was done using PCR-RFLP.
There were no significant differences in the genotypic frequencies of the DRD2TaqIA or the MAOA-uVNTR polymorphisms between the 2 groups. The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC + BP (odds ratio = 0.432, p = 0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC + BP (odds ratio = 3.451, p = 0.018).
We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC + BP.