Prenatal SSRI alters the hormonal and behavioral responses to stress in female mice: Possible role for glucocorticoid resistance
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- 作者：Ronit Avitsur ; avitsur@mta.ac.il" class="auth_mail" title="E-mail the corresponding author ; Rachel Grinshpahet ; Naama Goren ; Ido Weinstein ; Or Kirshenboim1 ; Noa Chlebowski1
- 关键词：Fluoxetine ; Glucocorticoid resistance ; Restraint stress ; SSRI ; Major depression disorder ; HPA axis
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：41-49
- 全文大小：684 K
文摘
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Prenatal fluoxetine increased corticosterone response to acute stress in adult mice.
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Prenatal fluoxetine raised corticosterone response to chronic stress in young mice.
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Prenatal fluoxetine diminished stress-induced anxiety-and depressive like behavior.
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Prenatal fluoxetine induced a state of glucocorticoid resistance.
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Findings indicate that prenatal SSRI exposure altered stress response.