Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources
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- 作者：Dan Xu ; Sheng-Xiang Lin ; sheng-xiang.lin@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; 17β-HSD1 ; 17β-HSD7 ; 3α-HSD3 ; siRNA knockdown ; DHEA ; E2 ; DHT
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：92-100
- 全文大小：1572 K
文摘
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Steroid enzymes may lead to different biological effects depending on the hormone source.
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17β-HSD1, 17β-HSD7, and 3α-HSD3 are potent targets for ER+-breast cancer.
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DHEA provision rationally mimics postmenopausal condition in steroid metabolism.