Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

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• 作者：Lisheng Wang^a ; ^{w_lsheng@163.com} ; Yejun You^a ; Songqing Wang^a ; Xu Liu^a ; Buming Liu^b ; Jinni Wang^c ; Xiao Lin^b ; Mingsheng Chen^b ; Gang Liang^c ; Hua Yang^a
• 关键词：Matrine derivative ; Synthesis ; Anti-tumor activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：15 June, 2012
• 年：2012
• 卷：22
• 期：12
• 页码：4100-4102
• 全文大小：425 K

文摘

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.