Chitosan-modified lipid nanovesicles for efficient systemic delivery of l-asparaginase
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- 作者：Shengli Wan1 ; Dan He1 ; Yuming Yuan ; Zijun Yan ; Xue Zhang ; Jingqing Zhang ; zjqrae01@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan modified lipid nanovesicles ; Systemic enzyme delivery ; Catalytic activity ; Therapeutic enzyme ; l-Asparaginase
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：143
- 期：Complete
- 页码：278-284
- 全文大小：1665 K
文摘
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Chitosan-lipid nanovesicles were applied to deliver therapeutic enzymes.
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ACLNs markedly increased the enzymatic activity and improved stabilities.
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ACLNs favorably changed the in vivo kinetic characteristics.
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ACLNs exhibited higher anti-lung-cancer activity than free ASP.
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The possible mechanisms for the enhanced properties of ASP were preliminary explored.