Antidiabetic activity of mycelia selenium-polysaccharide from Catathelasma ventricosum in STZ-induced diabetic mice

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• 作者：Yuntao Liu ; Jun Sun ; Shengqi Rao ; Yujie Su ; Junhua Li ; Caiming Li ; Shude Xu ; Yanjun Yang
• 关键词：Antidiabetic activity ; Mushroom ; Selenium-polysaccharides ; Streptozotocin-induced diabetic mice
• 刊名：Food and Chemical Toxicology
• 出版年：December, 2013
• 年：2013
• 卷：62
• 期：Complete
• 页码：285-291
• 全文大小：3027 K

文摘

Se-polysaccharide from Catathelasma ventricosum (SPC-2) was purified by DEAE-52 and Sephadex G-100 column chromatography. The average size of SPC-2 was 1.6 脳 10⁵ Da, and it was mainly composed of glucose (87.4%) with the conformation of 尾-pyran ring. The branched structure of SPC-2 was proved intuitively by atomic force microscope (AFM). The antidiabetic potential of SPC-2 was tested in STZ-induced diabetic mice. After STZ-induced diabetic mice being administered of SPC-2 for 30 days, SPC-2 treatment significantly reduced the levels of malondialdehyde (MDA) and low-density lipoprotein cholesterol (LDL-C) that were increased by the STZ treatment. Further, the SPC-2 treatment led to increased activity of antioxidant enzymes in liver and kidney and high-density lipoprotein cholesterol (HDL-C) that were decreased by the STZ. The results of histopathology also showed SPC-2 protected tissues (pancreas, liver and kidney) against peroxidation damage and maintained tissue integrity.