Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus

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• 作者：Anthony Ndirangu Kamau^a ; Jung-Eun Park^a ; Eui-Soon Park^c ; Jung-Eun Yu^c ; Jaerang Rho^c ; ; Hyun-Jin Shin ; DVM ; PhD^a ; ^b ; ^{shin0089@cnu.ac.kr}
• 关键词：Porcine epidemic diarrhea virus ; Porcine APN ; Pathogenesis ; Binding and entry ; Domain VII
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：150-157
• 全文大小：2479 K
• 卷排序：227

文摘

To gain insights into mechanisms of PEDV-pAPN interactions, the present study aimed at identifying the domain that is critical for PEDV binding. Results showed PEDV infection was restricted to pAPN domain VII expressing NIH3T3 cells. PEDV harvested from pAPN or domain VII expressing NIH3T3 cells was induced indirect plaques in Vero cells. Our results demonstrate that PEDV recognizes pAPN and that the main interactive point is lodged within domain VII of the pAPN.