Identification of a novel canine distemper virus B-cell epitope using a monoclonal antibody against nucleocapsid protein
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- 作者：Li Yi ; Yuening Cheng ; Miao Zhang ; Zhigang Cao ; Mingwei Tong ; Jianke Wang ; Hang Zhao ; Peng Lin ; Shipeng Cheng ; tcscsp@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Canine distemper virus ; Nucleocapsid protein ; Monoclonal antibody ; B-cell epitope
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：1-5
- 全文大小：1200 K
文摘
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LNFGRSYFDPA is a linear B-cell epitope of the CDV N protein.
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The alignment and comparison of the 1N8-defined epitope with other Morbillivirus sequences showed that the epitope is conserved among the Morbillivirus including Measles virus, Phocine distemper virus, Peste-des-petits-ruminants virus, and Rinderpest virus.
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The identified epitope can be recognized by CDV positive serum, it may be useful for clinical applications.