Risk factors of distant metastasis in patients with squamous cell carcinoma of the oral cavity

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• 作者：Yuki Sakamoto ; DDS^a ; ^{Yukiyama20@nagasaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yuki Matsushita ; DDS ; PhD^a ; Shin-ichi Yamada ; DDS ; PhD^a ; Souich Yanamoto ; DDS ; PhD^a ; Takeshi Shiraishi ; DDS ; PhD^b ; Izumi Asahina ; DDS ; PhD^b ; Masahiro Umeda ; DDS ; PhD^a
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：121
• 期：5
• 页码：474-480
• 全文大小：184 K

文摘

Although the locoregional control rate of oral cancer has improved recently, the number of patients developing distant metastasis (DM) has increased. The aim of this study is to investigate the clinicopathologic factors related to DM in patients with oral cancer undergoing surgery.

Study Design

This was a retrospective study of 252 patients who underwent surgery for squamous cell carcinoma of the oral cavity. Various clinicopathologic factors were examined to determine their relationship to the development of DM.

Results

DM occurred in 21 patients. Univariate analysis showed that perineural invasion, pathologically positive lymph nodes (pN+), neck metastasis level, extracapsular spread, local recurrence, neck recurrence, locoregional control, and postoperative radiotherapy were related to the occurrence of DM. According to multiple logistic analyses, pN+, involvement of neck levels 4 and 5, and local recurrence were independent risk factors for DM.

Conclusions

pN+, metastasis to the lower neck, and local recurrence were risk factors for DM in patients with oral cancer.