Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation
详细信息 查看全文
- 作者：Silvana Obici1 ; I. Jack Magrisso1 ; Armen S. Ghazarian2 ; Alireza Shirazian2 ; Jonas R. Miller2 ; Christine M. Loyd1 ; Denovan P. Begg1 ; 3 ; Kimberly A. Krawczewski Carhuatanta1 ; Michael K. Haas1 ; Jon F. Davis1 ; Stephen C. Woods1 ; Darleen A. Sandoval4 ; Randy J. Seeley4 ; Laurie J. Goodyear5 ; Emmanuel N. Pothos2 ; Joram D. Mul1 ; 5 ; Joram.Mul@joslin.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MC4R ; Nucleus accumbens ; Voluntary wheel running ; Dopamine ; Obesity ; Diabetes ; Food intake
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：4
- 期：10
- 页码：692-705
- 全文大小：3572 K
文摘
- •
MC4R-deficiency causes metabolic syndrome.
- •
Loss of MC4R signaling decreases voluntary wheel running (VWR).
- •
Despite moderate amounts of VWR, MC4R-associated metabolic syndrome is severely attenuated.
- •
MC4R-deficiency is associated with mesolimbic dopamine dysregulation during VWR.