Sticking It to Cancer with Molecular Glue for SHP2

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• 作者：Hao Ran¹ ; Ryouhei Tsutsumi¹ ; Toshiyuki Araki¹ ; Benjamin G. Neel¹ ; ^{benjamin.neel@nyumc.org" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：8 August 2016
• 年：2016
• 卷：30
• 期：2
• 页码：194-196
• 全文大小：418 K

文摘

Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.