The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew)
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- 作者：Sze Wa Chana ; 1 ; swchan@cihe.edu.hk" class="auth_mail ; Zengbing Lua ; jack_fun007@hotmail.com" class="auth_mail ; Ge Linb ; linge@cuhk.edu.hk" class="auth_mail ; David Tai Wai Yewa ; david-yew@cuhk.edu.hk" class="auth_mail ; Chi Kong Yeunga ; yeungck@rocketmail.com" class="auth_mail ; John A. Rudda ; jar@cuhk.edu.hk" class="auth_mail
- 关键词：Central nervous system ; Cisplatin ; Emesis ; Exendin (9&ndash ; 39) ; GLP-1 receptors ; Suncus murinus
- 刊名：Neuropharmacology
- 出版年：August 2014
- 年：2014
- 卷：83
- 期：Complete
- 页码：71-78
- 全文大小：1523 K
文摘
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Treatment with GLP-1 receptor agonists is sometimes associated with nausea and vomiting.
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Exendin-4-induced emesis is independent of 5-HT3 and NK1 receptors in Suncus murinus.
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Central GLP-1 receptors may be involved in emesis induced by cisplatin.
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GLP-1 receptor antagonists may represent a novel class of antiemetic.