Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin
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- 作者：Hrishikesh M. Revankar ; Manohar V. Kulkarni ; Shrinivas D. Joshi ; Uttam A. More
- 关键词：Ethyl gallate ; N-Benzoyl tyrosine ethyl ester ; Surflex-Dock ; Antimicrobial activity ; DNA gyrase subunit A
- 刊名：European Journal of Medicinal Chemistry
- 出版年：December, 2013
- 年：2013
- 卷：70
- 期：Complete
- 页码：750-757
- 全文大小：834 K
文摘
Two series of 4-aryloxymethyl coumarins derived from the reaction of 4-bromomethyl coumarins with ethyl gallate and ethyl ester of N-Benzoyl tyrosine have been synthesized. Gallate ethers dFont">3a-dFont">3g and tyrosine derivatives dFont">4e-dFont">4j were most effective against Entercoccus faecalis. They were also found to be effective against Aspergillus niger and Candida albicans. Comparative docking studies with novobiocin have indicated better binding ability and higher 鈥?em>C鈥?score values than novobiocin.