NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression
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- 作者：Yue Liu1 ; Tianqi Li1 ; Dan Hu ; Shuping Zhang ; bczhang@tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author ; shpzhang@biomed.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NOK/STYK1 ; Tumor growth ; Inner structure ; Angiogenesis ; Lymphangiogenesis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：254-259
- 全文大小：2121 K
文摘
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NOK overexpression in HeLa cells alternates the overall and inner structures of tumors.
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NOK overexpression enhances angiogenesis and change the morphology of blood vessels during tumor growth.
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NOK overexpression enhances lymphangiogenesis and causes the remodeling of lymphatic vessels during tumor progression.
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NOK expression was especially higher in the wall or surroundings of the tubular structures within cancerous tissues.
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The role of NOK in the re-establishment of these vascular systems is considered to bear significant clinical relevance.