Abiotic stress of ambient cold temperature regulates the host receptivity to pathogens by cell surfaced sialic acids
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- 作者：Seong-Cheol Moona ; 1 ; Su-Yeon Jooa ; 1 ; Tae-Wook Chunga ; 1 ; Hee-Jung Choia ; Mi-Ju Parka ; Hee-Jin Choia ; Sung-Jin Baeb ; Keuk-Jun Kimc ; Cheorl-Ho Kimd ; Myungsoo Jooa ; Ki-Tae Haa ; hagis@pusan.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cold temperature ; Sialic acid ; Sialyltransferase ; Hemagglutinin ; Virus ; Receptivity
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：476
- 期：3
- 页码：159-166
- 全文大小：2433 K
文摘
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We suggest a novel mechanism underlying cold-induced respiratory viral infection.
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Ambient cold increases the expression of cell surface sialic acids.
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Viral hemagglutinin binds to cold-induced sialic acid epitopes.
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Hemagglutinin binding was blocked by sialyltransferase inhibitor and sialyl-LacNac.