- 作者：Michal Kramer ; Mordechai R. Kramer ; Hannah Blau ; Jihad Bishara ; Ruth Axer-Siegel and Dov Weinberger
- 刊名：Ophthalmology
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：113
- 期：7
- 页码：1184-1186
- 全文大小：74 K
Objective
To describe the first use of intravitreal voriconazole in a human eye for the treatment of Aspergillus endophthalmitis.Design
Interventional case report.
Patient
A 22-year-old woman receiving immunosuppressive agents 5 weeks after lung transplantation who presented with blurred vision and redness in the right eye.
Interventions
Intravitreal injection of voriconazole (100 μg/0.1 ml) with pars plana vitrectomy, given after isolation of A. terreus in the vitreous sample. Previous treatment modalities, including vitrectomy with repeated intravitreal amphotericin B and systemic voriconazole, failed to prevent deterioration.
Main Outcome Measures
Visual acuity (VA) and ocular inflammation.
Results
Significant improvement was observed in VA (to 6/15) and in ocular inflammatory reaction. The patient recovered with no evidence of systemic fungal infection.
Conclusion
Intravitreal voriconazole may be used as an adjunct to systemic treatment in patients with Aspergillus endophthalmitis. Further clinical studies are needed to determine how often this approach can safely treat this condition.