Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane

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• 作者：Byongsun Lee^a ; Tae-Hee Lee^b ; Jaekyung Shim^a ; ^b ; ^{jkshim@sejong.ac.kr}
• 关键词：CSL ; CBF1/suppressor hairless/Lag-1 ; NEXT ; Notch1 extracellular truncation ; NICD ; Notch intracellular domain ; ADAM ; A disintegrin and metalloproteinase ; CoA ; Coactivators ; CoR ; Corepressors ; PM ; Plasma membrane ; NE ; Nuclear envelope ; NGPS ; Né ; stor-Guillermo progeria syndrome ; LEM ; LAP2-emerin-MAN1 ; TM ; Transmembrane
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：303-313
• 全文大小：1610 K
• 卷排序：1864

文摘

Emerin downregulated genes downstream of Notch signaling. Emerin interacted directly and colocalized with the NICD at the nuclear membrane. The downregulation of BAF or lamin A/C increased Notch signaling by inducing the release of emerin into the cytosol.