Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections
文摘
The largest RNA-Sequencing based transcriptome study in the muscle of T2DM. Expression of 56,318 genes on 92 T2DM cases and 184 controls were examined. A comprehensive list of genes and pathways altered in the muscle of T2DM. Downregulated genes were enriched in insulin signaling and metabolic pathways. Upregulated genes were enriched in apoptosis and immune response pathways.